Where to purchase am 2201

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Any other questions? Additional Information. Other People Also Viewed. Nakajima et al. An extracted ion spectrum is shown in Figure 3. Extracted ion spectrum of AM detected in an authentic herbal blend product. The chemical name of AM is 2-iodophenyl -[1-[[[ 2R methylpiperidinyl]methyl]-1H-indolyl]-methanone.

It is a novel potent cannabinoid compound that has not been reported in peer-reviewed literature as a compound detected in legal high products. This is the first published report of this cannabinoid found in an herbal blend product.

AM is a full agonist at the CB1 receptor and has a K i of 2. An extracted ion spectrum is shown in Figure 4. It has K i values of 9. At the time of detection, JWH was controlled by the state of Indiana, but it was found to be a constituent of blends named Cloud 9 Deversion 2. One other report has been published of the confirmed detection of this drug in legal high products. Also, Hudson et al. With the described method, JWH elutes at 6. It is a potent cannabinoid compound that exhibits K i values of 0.

At the time of detection, JWH was controlled by the state of Indiana, but it was found to be a constituent of several blends that were readily obtained, including 7H Kush, Cloud 9 Deversion 2. Kush, Mr.

Kush Blueberry , Mr. Kush Strawberry , No More Mr. JWH has been previously confirmed as an adulterant in herbal blend products by Ernst et al. Hudson et al. The chemical name of JWH is 2- 2-chlorophenyl 1-pentyl-1H-indolyl ethanone and it is a chlorophenylacetyl derivative of JWH It has K i values of 8. Previously published reports of the detection of this compound include Uchiyama et al. It is a very potent synthetic cannabinoid with K i values of 0. An extracted ion spectrum is shown in Figure 6.

Extracted ion spectrum of JWH detected in an authentic herbal blend product. The chemical name of JWH is 1- 1-pentyl-1H-indolyl 2-methoxyphenyl -ethanone and it is a 2-methoxyphenylacetyl derivative of JWH It was detected in one pre-federal ban product—K2 Silver—and multiple post-ban products—Cloud 9 Deversion 2. With the exception of the one pre-federal ban product, JWH was detected during times when the compound was considered a banned substance in the state of Indiana.

Uchiyama et al. The chemical name of RCS-8 is 1- 1- 2-cyclohexylethyl -1H-indolyl 2-methoxyphenyl ethanone and it is a cyclohexylethyl derivative of JWH Activity at the cannabinoid receptors has not been reported in literature.

At the time of detection, RCS-8 was a banned substance in Indiana. This is the first published report of the detection of this compound in an herbal incense blend. An extracted ion spectrum is shown in Figure 7. Extracted ion spectrum of RCS-8 detected in an authentic herbal blend product. The chemical name of 6-APB is alpha-methylbenzofuranethanamine.

It is considered a substituted amphetamine drug and is most similar to 3,4-methylenedioxyamphetamine MDA , but it is not scheduled in the United States.

Toxicological data are not available for this drug because it has not been reported in literature. This is the first published report of the detection of this compound in a legal high product.

The isomeric compound, 5-APB, also exists, but at the time of publishing, we did not have access to a reference standard to verify retention time and whether any chromatographic resolution exists between 5-APB and 6-APB. Alpha-PVP is also known as alpha-pyrrolidinopentiophenone or desmethylpyrovalerone, a stimulant drug that was developed and patented in the s.

It is an derivative of MDPV; the only difference is the removal of the 3,4-methylenedioxy group. Alpha-PVP was detected in a product named Speed Rush, which was similar to the Mind Candy product, which was sold in a smoke shop as a package of two light-orange colored unmarked pills. It was also detected in a product named Crystal Clean Hookah and Pipe Cleaner, which was supplied as a tan-colored powder and sold in a gas station convenience store, and Vanilla Sky, a white-colored powder sold in a smoke-shop.

This is the first published report of the detection of this compound in legal high products. An extracted ion spectrum is shown in Figure 8.

Extracted ion spectrum of Alpha-PVP detected in an authentic legal high product. Butylone's chemical name is Beta-keto- N -methylbenzodioxolylpropylamine. It is the beta ketone derivative of the designer drug MBDB Eden and also a derivative of the Schedule 1 drug methcathinone. Butylone was detected in a product named Mexican Jumping Beans, which was supplied as three capsules containing a tan-colored powdery substance. Butylone has been detected in previous legal high drugs by Brandt et al.

MPPP's chemical name is 2- pyrrolidinyl p-tolyl propanone. It is included in a group of compounds called pyrrolidinophenones. Brandt et al. In four circumstances, we analyzed multiple packages of the same legal high product. In two other cases, we detected unsuspected drugs, lidocaine and phenazepam, which are neither synthetic cannabinoids nor stimulants. We analyzed five packages of the product named Cloud 9 Deversion 2. All four of these second-generation products were obtained at different locations at different times around Indiana.

The second product contained only JWH The fourth and fifth products contained only AM We analyzed seven packages of the product named Cloud 9 Mad Hatter. The packages of second-generation material were obtained at different locations around Indiana. We analyzed two packages of the product named Demon. The packages of material were obtained at the same location convenience store in Indiana. The anesthetic and anti-arrhythmic drug lidocaine was detected as an adulterant in the herbal blend product Funky Monkey Black Label.

The use of caffeine, lidocaine or procaine in legal high products has been reported by Brandt et al. Multiple replicates of this blend were analyzed to verify that the positive result was true and the LC—TOF results were confirmed by an multiple reaction monitoring-based liquid chromatography—tandem mass spectrometry LC—MS-MS methodology specific for lidocaine; no quantitation was performed.

Lidocaine was not detected in any other product that we analyzed. The potent benzodiazepine phenazepam was detected in the blend product Ultra Zombie Matter. Phenzepam is primarily used in Russia and other former Soviet republics; it is unscheduled in the United States This is the first documented appearance of this drug in a legal high product. Phenazepam is legal to possess and consume in the United States.

We analyzed two packages of the product named Tranquility. The first product was obtained during the pre-federal ban time frame and contained MDPV, while the second product was obtained during the post-federal ban time frame and contained methylone, which was one of the three federally banned stimulants.

At the time of purchase, methylone was a banned substance in Indiana. In our study of first-generation and second-generation products, it was shown that as compounds become banned or controlled, the manufacturers switch the active drug or drugs in the legal high product so that it stays legal and able to be sold.

It was also shown that even within the same product or packaging, different drugs or combinations of drugs may be present.

To keep up with these moving targets, instrumentation and methodologies need to be adapted that allow a laboratory to acquire highly specific data in full scan mode.

As these products evolve over time, modifications will be made to the methods in the future through the incorporation of additional compounds. Also, the use of isotopic patterns and spacing will be incorporated into the identification procedures.

The authors would like to thank Dr. Google Scholar. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Shanks , Kevin G. Email: kshanks aitlabs.

Oxford Academic. Tim Dahn. George Behonick. Andrea Terrell. Cite Cite Kevin G. Select Format Select format. Permissions Icon Permissions. Table I Elution Gradients. Synthetic cannabinoids. Total time min. Initial 58 42 0. Open in new tab. Molecular formula. Retention time min. Product Name. Time period acquired. Compound s detected. Figure 1. Open in new tab Download slide.